Does CCleaner Network support Windows Domains?
Yes. You just need to add your LDAP information and then scan your network. All of your hosts and directory accounts will be imported in a few seconds and will be organized in the network tree using the same structure as your Organization Units.
How do roaming profiles work with CCleaner Network?
CCleaner Network treats roaming profiles in exactly the same was as normal profiles. So, you will need to install the Endpoint Agent on every Endpoint that you wish to clean.
This applies to the Domain Controller (DC) too. So, if you install the Agent on the DC, you will be able to clean all of the profiles of users that that have logged into the DC.
You can find information on how to enter LDAP information in the management console here.